How does vitamin D supplementation impact COVID-19 vaccine efficacy? medrxivpreprint QMUL SARSCoV2 COVID19 Vaccine VitaminD Vaccination
By Bhavana KunkalikarJul 20 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers assessed the impact of vitamin D supplementation on the efficacy of severe acute respiratory syndrome coronavirus 2 vaccines.
The team performed three sub-studies conducted within the CORONAVIT randomized controlled trial. Among these, sub-study 1 performed vaccine efficacy analysis to assess the effect of vitamin D supplementation on the risk of breakthrough COVID-19 infection among immunocompetent participants vaccinated with two SARS-CoV-2 vaccine doses.
Related StoriesThe eligible participants were subsequently randomized before determining the concentrations of 25D in their capillary blood. Participants who had a 25D concentration of less than 75 nmol/L were given a six-month supply of capsules comprising either 800 IU or 3200 IU vitamin D3. In comparison, those having 25D concentrations of 75 nmol/L or above were treated with a second postal vitamin D test two months after the first test.
For the participants whose baseline vitamin D concentrations were assessed, the average 25D level was 39.9 nmol/L. On the other hand, participants that were assessed for end-study vitamin D concentrations showed that the follow-up 25D concentrations were higher among the participants who were treated with lower-dose supplements as compared to the untreated participants.
Belgique Dernières Nouvelles, Belgique Actualités
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