How human cell atlases provide the missing links between genes, diseases and therapies HumanCellAtlas Genes Blood Cancer Diagnostic Genetic Genomic Medicine Therapeutics NatureMedicine genentech sangerinstitute Cambridge_Uni
Study: Impact of the Human Cell Atlas on medicine. Image Credit: Giovanni Cancemi / Shutterstock
The community has contributed significantly during the ongoing coronavirus disease 2019 pandemic in terms of providing early information on the susceptibility of cells to infection and the clinical consequences of infection in the body. Both healthy and disease atlases of specific tissues have made it possible to connect disease genes to specific cell subsets in various inflammatory, autoimmune, respiratory, and neurodegenerative diseases.
In Crohn's disease, comparing cellular composition in the affected ileum with the healthy reference atlas has led to the identification of a unique multicellular community of immune and stromal cells, which is predictive of a lack of anti-TNF therapy response. Cell atlases in disease diagnosis and treatment Healthy reference atlases, disease atlases, laboratory techniques, and computational programs have opened up a new path toward developing more advanced diagnostic assays with higher resolution and broader molecular scope.
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Cannabis Recreational Legalization and Prevalence of Simultaneous Cannabis and Alcohol Use in the United States - Journal of General Internal MedicineBackground Simultaneous cannabis/alcohol use, using both substances within a short time interval so that their effects overlap, has a greater risk of potential negative consequences than single-substance use and is more common in younger age. Relationships between recreational cannabis laws (RCLs) and changes in simultaneous cannabis/alcohol use prevalence remain untested. Objective To examine trends in simultaneous cannabis/alcohol use from 2008 to 2019, and investigate associations between implementation of RCLs (i.e., presence of active legal dispensaries or legal home cultivation) and simultaneous cannabis/alcohol use in the United States (U.S.). Design Repeated cross-sectional samples from the 2008–2019 U.S. National Survey on Drug Use and Health (NSDUH). Participants Respondents (51% female) aged 12 and older. Interventions Changes in simultaneous cannabis/alcohol use before and after RCL implementation (controlling for medical cannabis law implementation) were compared in different age groups (12–20, 21–30, 31–40, 41–50, 51+), using adjusted multi-level logistic regression with state random intercepts and an RCL/age group interaction. Measurements Self-reported simultaneous cannabis/alcohol use. Results From 2008 to 2019, the overall prevalence of simultaneous cannabis/alcohol use declined among those aged 12–20 but increased in adults aged 21+. Model-based simultaneous cannabis/alcohol use prevalence increased after RCL implementation among respondents aged 21–30 years (+1.2%; aOR=1.15 [95%CI=1.04–1.27]), 31–40 years (+1.0; 1.15 [1.04–1.27]), and 41–50 years (+1.75; 1.63 [1.34–1.98]), but not in individuals aged |21 or 51+ years. Conclusions Implementation of recreational cannabis policies resulted in increased simultaneous use of cannabis and alcohol, supporting the complementarity hypothesis, but only among adults aged 21+. Efforts to minimize harms related to simultaneous cannabis/alcohol use are critical, especially in states with RCLs. Future studies sh
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Here is everything you need to know about the DWP Christmas Bonus including who is eligibleThe Department for Work and Pensions (DWP) are providing a Christmas Bonus for people on certain benefits amid the cost of living crisis - here is everything you need to know.
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