'How many more warriors will die': Rob Burrow's plea to government over missing £50m MND funding

Belgique Nouvelles Nouvelles

'How many more warriors will die': Rob Burrow's plea to government over missing £50m MND funding
Belgique Dernières Nouvelles,Belgique Actualités
  • 📰 LeedsNews
  • ⏱ Reading Time:
  • 32 sec. here
  • 2 min. at publisher
  • 📊 Quality Score:
  • News: 16%
  • Publisher: 63%

The Health Secretary has pledged to make an announcement on motor neurone disease research funding “in days”

“How many more warriors die before this stupid government give the 50m they said they would give,” Burrow said on Twitter.Challenged about the statement on BBC Breakfast, Health Secretary Steve Barclay said: “It’s a massive priority because I have so much respect for what Rob has done, for what Kevin has done, for Doddie Weir and Ed Slater the Gloucestershire and former England and Leicester player. It’s something I’ve taken a huge personal interest in.

“I prioritise that. I’m expecting to be in a position to announce something very, very shortly on that and really to address Rob’s concern.”MND charities and LifeArc on behalf of the United To End MND coalition, said in a statement: “We look forward to hearing more from Steve Barclay following his comments on BBC Breakfast this morning that there will be a further announcement in ‘days not weeks’ around the £50 million pledged by the Government last year for targeted MND research.

“This approach could be a way to access the £50 million while ensuring appropriate peer review and value for money.”

Nous avons résumé cette actualité afin que vous puissiez la lire rapidement. Si l'actualité vous intéresse, vous pouvez lire le texte intégral ici. Lire la suite:

LeedsNews /  🏆 48. in UK

Belgique Dernières Nouvelles, Belgique Actualités

Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.

Kevin Sinfield inspires Leeds dad's festive 'reindeer route' for MNDKevin Sinfield inspires Leeds dad's festive 'reindeer route' for MNDHe praised Rob Burrow and Kevin Sinfield for their fundraising efforts
Lire la suite »

BBC Radio Shropshire - Adam Green, 07/12/2022, Supreme Court for Greenfields capaignersBBC Radio Shropshire - Adam Green, 07/12/2022, Supreme Court for Greenfields capaignersToday is a massive day for a group of Greenfields residents in Shrewsbury. Their campaign to save part of their local recreation ground from being developed on will be heard in the Supreme Court- the highest court in the land.
Lire la suite »

RIVERSIDE MOTOR GROUP SALE: Buy a used car and drive off with a Mediterranean breakRIVERSIDE MOTOR GROUP SALE: Buy a used car and drive off with a Mediterranean breakFREE seven night CostaDelSol or Tenerife stay for two when you buy a used car in December 2022 RiversideMotorG in Barnsley Doncaster Wakefield & Hull - see BiggestEverWinterSale story See details, t&cs & used cars at ad
Lire la suite »

The SYNGAP1 3′UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPKThe SYNGAP1 3′UTR Variant in ALS Patients Causes Aberrant SYNGAP1 Splicing and Dendritic Spine Loss by Recruiting HNRNPKFused in sarcoma (FUS) is a pathogenic RNA-binding protein in amyotrophic lateral sclerosis (ALS). We previously reported that FUS stabilizes Synaptic Ras-GTPase activating protein 1 ( Syngap1 ) mRNA at its 3′ untranslated region (UTR) and maintains spine maturation. To elucidate the pathologic roles of this mechanism in ALS patients, we identified the SYNGAP1 3′UTR variant rs149438267 in seven (four males and three females) out of 807 ALS patients at the FUS binding site from a multicenter cohort in Japan. Human-induced pluripotent stem cell (hiPSC)-derived motor neurons with the SYNGAP1 variant showed aberrant splicing, increased isoform α1 levels, and decreased isoform γ levels, which caused dendritic spine loss. Moreover, the SYNGAP1 variant excessively recruited FUS and heterogeneous nuclear ribonucleoprotein K (HNRNPK), and antisense oligonucleotides (ASOs) blocking HNRNPK altered aberrant splicing and ameliorated dendritic spine loss. These data suggest that excessive recruitment of RNA-binding proteins, especially HNRNPK, as well as changes in SYNGAP1 isoforms, are crucial for spine formation in motor neurons. SIGNIFICANCE STATEMENT It is not yet known which RNAs cause the pathogenesis of amyotrophic lateral sclerosis (ALS). We previously reported that Fused in sarcoma (FUS), a pathogenic RNA-binding protein in ALS, stabilizes synaptic Ras-GTPase activating protein 1 ( Syngap1 ) mRNA at its 3′ untranslated region (UTR) and maintains dendritic spine maturation. To elucidate whether this mechanism is crucial for ALS, we identified the SYNGAP1 3′UTR variant rs149438267 at the FUS binding site. Human-induced pluripotent stem cell (hiPSC)-derived motor neurons with the SYNGAP1 variant showed aberrant splicing, which caused dendritic spine loss along with excessive recruitment of FUS and heterogeneous nuclear ribonucleoprotein K (HNRNPK). Our findings that dendritic spine loss is because of excess recruitment of RNA-binding proteins provide a basis for the future
Lire la suite »

Aussie road rage driver chased cyclist and smashed SUV through suburban fencesAussie road rage driver chased cyclist and smashed SUV through suburban fencesThe enraged woman 'turned her vehicle into a weapon' and chased a cyclist through a suburban neighbourhood, making 'racial accusations' and smashing the SUV through garden fences in her pursuit of the victim cycling
Lire la suite »



Render Time: 2025-04-01 15:11:56