How neurons autonomously regulate their excitability CellReports
knows how much the volume matters: Shouting into the microphone results in a distorted and unclear recording. But whispering is not a good idea either—then the result is too quiet and also difficult to understand. That is why sound engineers ensure the perfect sound at every concert and talk show: They regulate each microphone's gain to match the input signal.
For example, they need to dial down their sensitivity if the incoming stimuli were very strong."We have now discovered that a specific enzyme called SLK plays a role in this process," says Beck, who is also spokesperson for the Transdisciplinary Research Area"Life and Health" at the University of Bonn."It enables neurons to individually calibrate their own excitability.
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