HUNDREDS of women with breast cancer will get months of extra life thanks to a new NHS drug. Patients with an incurable type of cancer called HER2-positive will be offered the medicine Enhertu to s…
HUNDREDS of women with breast cancer will get months of extra life thanks to a new NHS drug.called HER2-positive will be offered the medicine Enhertu to slow down its progress.The new drug can halve certain patients' risk of disease progression or death within the first 18 months of taking itAround 600 women per year in England are expected to benefit when their cancer comes back after treatment.
Trials found the drug, known as trastuzumab deruxtecan, can halve certain patients’ risk of disease progression or death within the first 18 months of taking it. It increased the amount of time without tumour growth to an average of 9.9 months, from 5.1 months with standardPeter Clark, from NHS England’s Cancer Drugs Fund, said: “This cutting-edge drug will give hundreds of patients with secondary incurable
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Frontiers | Loss of perceived social role, an index of social frailty, is an independent predictor of future adverse events in hospitalized patients with heart failureAims Although the impact of physical frailty on prognosis and the effect of cardiac rehabilitation in HF patients has been well established, data for the prognostic impact of social frailty (SF) in HF patients are limited. In addition, the relative importance of each SF domain in clinical outcomes remains unclear. We aimed to get a new insight into the associations of SF with clinical outcomes in elderly hospitalized HF patients. Methods A single-center, retrospective cohort study was conducted using data from 310 in-hospital HF patients aged ≥ 65 years (mean age of 78 ± 8 years; 49% women). Makizako’s five questions, a self-reported questionnaire, were used to define SF. The primary outcome was composite events defined by all-cause death and cardiovascular events. Results Of the 310 elderly HF patients, 189 patients (61%) had SF. Seventy-five patients (24%) had composite events during a mean follow-up period of 1.93 ± 0.91 years. Kaplan-Meier curves showed that patients with SF had a significantly higher composite event rate than patients without SF. In multivariate Cox regression analyses, SF was independently associated with a higher composite event rate after adjusting for prognostic markers [adjusted hazard ratio (HR), 2.01; 95% confidence interval (CI), 1.07 to 3.78; p=0.04]. Of the 5 questions for defining SF, an answer of yes to the question about not feeling helpful toward friends or family, which indicates loss of perceived social role, was an independent predictor of composite events (adjusted HR, 2.28; 95% CI, 1.36 to 3.82; p | 0.01). Inclusion of loss of perceived social role into the baseline prognostic model improved both the continuous net reclassification improvement (0.562; 95% CI, 0.298 to 0.827; p | 0.01) and integrated discrimination improvement (0.031; 95% CI, 0.006 to 0.056; p=0.02). Conclusion Loss of perceived social role is associated with increased adverse event risk and provides additive prognostic information in elderly HF patients.
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