Protein Grb10 offers a potential new approach for treating obesity BCMHouston
a. Schematic diagram of virus injection into the ARH. b. Beta-endorphin immunofluorescence staining in the ARH with POMC neurons infected with AAV-DIO-Grb10-GFP. c. Quantification for the percentage of beta-endorphinGFP cells . d. Representative Grb10 immunofluorescence staining in the ARH with one side of the POMC neurons infected with AAV-DIO-GFP and the other side infected with AAV-DIO-Grb10-GFP . e. Representative immunofluorescence images of GFP and Grb10 expression in the ARH. f.
Extended Data Fig. 10 Grb10 overexpression in POMC neurons ameliorates the development of obesity in HFD-fed male and female mice. a-b. Body weight and percentage of mass weight in HFD-fed male control and POMC-Grb10-OE mice. c-d. Area under curve for GTT and ITT in HFD-fed male control and POMC-Grb10-OE mice. e-i. Body weight , weight gain , body composition and cumulative food intake in HFD-fed female control and POMC-Grb10-OE mice. j.
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