'I’m a make-up pro - six beauty moves that are making you look older'
“As well as this, opting for a shade that is slightly brighter than your skin tone will help to add warmth and a youthful illusion, while one that is too dark could end up having the opposite effect.Blush can be the ideal way to add a fun and flirty splash of colour to your cheeks.
Reaching for a cream or lightweight powder blush offers the option to play around with different shades and coverages, to find out which one suits you the best. But avoiding making your under-eye area darker doesn’t have to mean losing your identity and individuality. It can always be tempting to go a bit overboard with the contouring brush, but this can actually leave dark shadows and streaks if not blended in properly.
Karen Betts advises: “Always follow the lines of your bone structure, allowing the brush to glide along your cheekbones, jawline and anywhere else you feel needs a touch more definition.
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Solitary and multiple thyroid nodules as predictors of malignancy: a systematic review and meta-analysis - Thyroid ResearchBackground The debate on whether or not there is a difference in the incidence of thyroid cancer between the patients with Solitary thyroid Nodule (STN) and Multinodular Goiter (MNG) has been constantly present for the last few decades. With newer studies yielding mixed results, it was imperative to systematically compile all available literature on the topic. Methods PubMed/MEDLINE, Cochrane Central, ScienceDirect, GoogleScholar, International Clinical Trials registry, and reference lists of the included articles were systematically searched for article retrieval. No filter was applied in terms of time, study design, language or country of publication. Rigorous screening as per PRISMA guidelines was undertaken by 2 independent reviewers in order to identify the articles that were most relevant to the topic. Results Twenty-two studies spanning from 1992 to 2018 were included in this analysis and encompassed 50,321 patients, 44.2% of which belonged to the STN subgroup and 55.37% to the MNG subgroup. MNG was found to be associated with a significantly lower risk of thyroid cancer (OR = 0.76; 95% CI 0.61–0.96) when compared with STN. Papillary carcinoma was the most frequently occurring carcinoma across both groups, followed by follicular and medullary carcinomas. A subgroup analysis was performed to assess the efficacy of the two most commonly employed diagnostic tools i.e. surgery and fine needle aspiration cytology (FNAC), however it yielded nonsignificant results, indicating a comparable usefulness of the two. Another subgroup analysis run on the basis of the presumed iodine status of the participants also yielded nonsignificant results. Conclusion There is a higher incidence of thyroid cancer among patients of STN, however, given the low quality of existing evidence on the topic, it is crucial to conduct larger studies that can establish association with a greater precision.
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