IL-9 identified as contributor to viral spread and airway inflammation in COVID-19 NatureComms IL9 interleukin covid COVID19 SARSCoV2
By Neha MathurJul 13 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature Communications, researchers used a K18-hACE2 transgenic mouse model to demonstrate that interleukin-9 plays a crucial role in coronavirus disease 2019 pathogenesis.
Thus, anti-inflammatory drugs, like dexamethasone, could lower the severity of COVID-19-induced respiratory symptoms and lower mortality. In general, immune suppression is an effective COVID-19 mitigation tool, at least against pulmonary pathologies of COVID-19. About the study The present study used six- to eight-week-old male and female hACE2.Tg mice to administer live SARS-CoV-2 and perform all the study experiments. They cohoused infected mice with the uninfected ACE2.Tg mice in a 1:1 ratio 24 hours post-infection to monitor mice for COVID-19 symptoms and measure their other parameters.
The team further normalized the relative gene expression levels by log2 transformation to calculate Z-scores. Eventually, they represented the median of Z-scores of log2 transformed relative gene expression as a heat map. Accordingly, they noted that IL-9 was upregulated in SARS-CoV2-infected-ACE2.Tg mice, whereas its depletion enhanced viral clearance by regulating SARS-CoV-2-induced airway inflammation and lung pathology.
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