Wafer-thin device has potential to transform the field of islet cell transplantation MethodistHosp NatureComms
. Finally, NICHE was resected en bloc, with intact fibrotic capsule and islets retained within the cell reservoir, underscoring feasible and safe retrieval.
In sum, the NICHE integrates direct vascularization and local immunosuppression into a single, implantable, replenishable device for allogeneic islet transplantation and long-term type 1 diabetes management. The results from this study demonstrate NICHE efficacy in rats and pave a path towards continued translational development of the approach.
For NHP studies, a 5-year-old male Mauritian cynomolgus monkey purchased from the Mannheimer Foundation, Inc. through the University of Miami Division of Veterinary Resources was used as donor. The donor NHP was kept at the University of Miami animal facility. Female Vietnamese cynomolgus macaques , were used for biocompatibility studies and as recipients for islet transplant studies . Recipient NHPs were kept at the AAALAC-I accredited Michale E.
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