One of the hallmarks of Alzheimer's disease is disruption to the body's circadian rhythm, the internal biological clock that regulates many of our physiological processes. Nearly 80% of people with Alzheimer's experience these issues, including difficulty sleeping and worsening cognitive function at night. However, there are no existing treatments for Alzheimer's that target this aspect of the disease.
A new study from researchers at University of California San Diego School of Medicine has shown in mice that it is possible to correct the circadian disruptions seen in Alzheimer's disease with time-restricted feeding, a type of intermittent fasting focused on limiting the daily eating window without limiting the amount of food consumed.showed improvements in memory and reduced accumulation of amyloid proteins in the brain.
"For many years, we assumed that the circadian disruptions seen in people with Alzheimer's are a result of neurodegeneration, but we're now learning it may be the other way around—circadianmay be one of the main drivers of Alzheimer's pathology," said senior study author Paula Desplats, Ph.D., professor in the Department of Neurosciences at UC San Diego School of Medicine.
Alzheimer's disease affects more than 6 million Americans, and it is considered by many to be the biggest forthcoming health challenge in the United States. People with Alzheimer's experience a variety of disruptions to their, including changes to their sleep/wake cycle, increased cognitive impairment and confusion in the evenings, and difficulty falling and staying asleep.
"Circadian disruptions in Alzheimer's are the leading cause of nursing home placement," said Desplats."Anything we can do to help patients restore their circadian rhythm will make a huge difference in how we manage Alzheimer's in the clinic and how caregivers help patients manage the disease at home."is an emerging approach to improving health outcomes, and one way to accomplish this is by controlling the daily cycle of feeding and fasting.
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