Investigators uncover new braincircuit for epilepsy brighamwomens jamaneuro
"We're learning more and more about where in the brain epilepsy comes from and what brain circuits we need to modulate to treat patients with epilepsy," said lead author Frederic Schaper, MD, Ph.D., an Instructor of Neurology at Harvard Medical School and scientist at the Brigham and Women's Center for Brain Circuit Therapeutics.
The Brigham researchers compared the locations of brain damage in patients that developed epilepsy to patients that did not, and found that lesions associated with epilepsy were distributed throughout the brain. However, these same lesion locations were connected to a common brain network, suggesting the brain connections disrupted by the lesions, rather than the locations of the lesions itself, were the key.for predicting the risk of epilepsy after brain damage.
The key brain connections they identified were not on the brain's surface but were located deep within the brain in regions called the basal ganglia and cerebellum. The authors state that for decades, these deep brain structures have shown to modulate and control seizures in animal models of epilepsy and are hypothesized to act like a brain"brake."
"When programming a DBS electrode to improve seizures, it's hard to know which spot to stimulate because it can take months before the patient's seizures improve" said senior author Michael Fox, MD, Ph.D., an Associate Professor of Neurology at Harvard Medical School and founding director of the Brigham and Women's Center for Brain Circuit Therapeutics."Identifying this brain circuit for epilepsy may help us target the right spot to improve patient outcomes.
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