The association between obesity and head and neck cancer risk.
By Tarun Sai LomteAug 29 2023Reviewed by Lily Ramsey, LLM In a recent study published in BMC Medical Genomics, researchers assessed the association between obesity and head and neck cancer risk.
Obesity has been associated with numerous cancers; it is considered a common and modifiable risk factor. Recent studies suggest that obesity is associated with head and neck cancer. By contrast, Mendelian randomization analyses, which use genetic variants to assess the causal associations, may reduce bias from confounding or reverse causality.
Outcomes were 1) overall head and neck cancer, 2) oropharyngeal cancer, 3) oral cavity cancer, and 4) oropharyngeal and oral cavity cancer. SNPs with genome-wide significance and not in linkage disequilibrium were selected, whereas those with minor allele frequency below 0.01 were excluded. Odds ratios and 95% confidence intervals were computed; p-values < 0.00139 were statistically significant, and those between 0.00139 and 0.05 were deemed to have suggestive significance.
BMI might be negatively associated with the risk of oropharyngeal, oral cavity, or oral cavity and oropharyngeal cancer.
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