Issues and recommendations for the residual approach to quantifying cognitive resilience and reserve - Alzheimer's Research & Therapy

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Issues and recommendations for the residual approach to quantifying cognitive resilience and reserve - Alzheimer's Research & Therapy
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Caution should be taken in the use and interpretation of the residual-based method of cognitive resilience, according to a study published in Alzheimer's Research & Therapy.

In this way, we encourage those interested in studying resilience to consider reconceptualizing the objectives of these analyses. Modeling the contribution of various adverse and protective factors will allow us to make better predictions about cognitive decline. By continuing to discover and quantify such factors, we can slowly reduce the unexplained variance in cognitive decline and come up with more accurate forecasts of cognitive decline .

With better models for cognition, we shift our focus to simulating how modification of a pathological or resilience factor might influence maintenance of healthy cognitionAlthough we recommend against using residual approaches to quantify resilience, we note that these approaches can be appropriate in other contexts such as adjusting a measure for confounding factors.

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