Researchers ID novel treatment pathway for deadly pancreatic cancers jclinicalinvest
). These studies, together with our results, suggest that the stroma has multiple functions, which may depend on tumor stage and properties of tumor cells, and stromal composition. The stroma could provide an initial barrier that is circumvented as tumor cells become more plastic . While we could not dissect the contribution of the stroma in isolation, our models suggest that HMGA1 and FGF19 collaborate to promote tumor progression and stroma formation.
FGF19 is a pleiotropic, hormone-like protein that regulates lipid, carbohydrate, and bile acid metabolism through the receptor FGFR4 (
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