Actors Katherine Parkinson and Youssef Kerkour join forces in brand new ITV dark comedy where they play neighbours who end up exploring a problematic romance
If you don’t like traditionally romantic comedies, this “unromantic romantic comedy” might be just what you’re looking for.
“They’re a very unlikely pair, who come together at a point in their lives where they are each in a sort of extreme place,” explains Youssef. “All the obstacles in their life blind them to the fact that maybe the right person for them is living right next door.” “We were lucky, we both had our partners and daughters on set a lot as well and everyone was very tolerant of that,” adds Katherine.
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Neuropathology of incidental Lewy body & prodromal Parkinson’s disease - Molecular NeurodegenerationBackground Parkinson’s disease (PD) is a progressive neurodegenerative disorder associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there is currently no disease-modifying treatment to halt neuronal loss in PD. A major hurdle for developing and testing such curative therapies results from the fact that most DA neurons are already lost at the time of the clinical diagnosis, rendering them inaccessible to therapy. Understanding the early pathological changes that precede Lewy body pathology (LBP) and cell loss in PD will likely support the identification of novel diagnostic and therapeutic strategies and help to differentiate LBP-dependent and -independent alterations. Several previous studies identified such specific molecular and cellular changes that occur prior to the appearance of Lewy bodies (LBs) in DA neurons, but a concise map of such early disease events is currently missing. Methods Here, we conducted a literature review to identify and discuss the results of previous studies that investigated cases with incidental Lewy body disease (iLBD), a presumed pathological precursor of PD. Results Collectively, our review demonstrates numerous cellular and molecular neuropathological changes occurring prior to the appearance of LBs in DA neurons. Conclusions Our review provides the reader with a summary of early pathological events in PD that may support the identification of novel therapeutic and diagnostic targets and aid to the development of disease-modifying strategies in PD.
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Laura Woods slams Man Utd chief for 'really bloody awkward' presentation of Alessia Russo awardShiels says he is 'upset' by the backlash after the Man Utd end-of-season awards and 'would have done the same if presenting to a male player'. Hmmm.
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Man United foundation chief apologises for 'awkward' award joke to Alessia RussoThe chief executive of the Manchester United foundation has apologised after joking to Alessia Russo her Women’s Player of the Year trophy was ‘too heavy’ for her. John Shiels has come under fire f…
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The One Show's Angellica Bell in awkward failed TV magic trickThe One Show's Angellica Bell in awkward failed magic trick moment
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