Study gives a peek at how ketamine acts as 'switch' in the brain pennmedicine NatureNeuro
Nature Neuroscience
thanks Jordan Hamm, Ken Solt and the other, anonymous, reviewer for their contribution to the peer review of this work.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Duration effect of single dose of ketamine or saline on time for complete removal of adhesive from snout and forelimb withdrawal response to air puff . Example images of marble burial test under different conditions.
. Representative fluorescent traces of individual L2/3 axonal boutons imaged in layer 1 under wakefulness and KET 100 mg/kg. Line scatterplots of individual boutons before and after KET 100 mg/kg reveals emergence of a switch. Difference in calcium activity induced by KET at 10 mg/kg or 150 mg/kg IP from baseline wakefulness
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