Researchers explore the involvement and altered expression of BBOX1-AS1 and microRNA-19b in polycystic ovary syndrome.
By Neha MathurSep 26 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in BMC Women's Health, researchers explore the involvement and altered expression of BBOX1 antisense ribonucleic acid 1 and microRNA-19b in polycystic ovary syndrome .
PCOS is a clinical disorder that affects 4-12% of women of reproductive age. Since PCOS affects ovaries, the researchers of the current study hypothesized that BBOX1-AS1 also interacts with miR-19b to participate in PCOS. These hormonal imbalances manifest as numerous cysts in the ovary, which, without proper treatment, reduce egg quality, prevent ovulation, and lead to infertility. To date, the cause of PCOS is unknown.
Previous studies have reported the downregulation of MiR-19b in PCOS and how it enhances granulosa cell proliferation; however, its upstream regulator is unknown. Nevertheless, miR-19b may be a potential molecular target of PCOS treatment. All study participants received the first round of in-vitro fertilization treatment at Hainan Women and Children Medical Center in China to donate follicular fluid samples for this study. The control group comprised 80 females who received IVF treatment because of male factors, rather than a PCOS diagnosis.
Study findings In striking contrast to miR-19b, BBOX1-AS1 was highly upregulated in PCOS. These findings demonstrate the role of BBOX1-AS1 in PCOS, similar to its involvement with several different ovarian disorders.
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