Light to moderate alcohol consumption lowers cardiovascular risk through stress reduction ChronicStress Cardiovascular Health Alcohol Consumption MACErisk Cardiology HeartHealth JACCJournals
By Dr. Priyom Bose, Ph.D.Jun 15 2023Reviewed by Benedette Cuffari, M.Sc. Major adverse cardiovascular events through heightened stress-related neural network activity are associated with chronic stress. Previous research has shown that light or moderate alcohol consumption could be correlated with lower MACE risk, although the precise mechanisms remain unclear.
Background Compared to abstinence, light/moderate alcohol use has been linked to lower MACE risk. However, it remains unclear whether this beneficial effect is due to alcohol itself or from confounding factors such as socioeconomic status or associated health behaviors. A deeper understanding of the underlying mechanisms is needed to develop novel treatments mimicking similar benefits without the harmful effects of alcohol.
The researchers also determined whether this effect mediated the benefits of light/moderate alcohol consumption on MACE. The potentially stronger influence of light/moderate alcohol use on MACE in individuals expected to have chronically heightened SNA was also investigated. Light/moderate alcohol consumption was also associated with stronger effects on cardiovascular disease risk reduction among individuals with a history of anxiety. These findings imply that alcohol could improve MACE risk, and interventions targeting SNAs may improve CVD outcomes. However, alternative approaches to reduce SNA are needed, as light/moderate alcohol consumption could also lead to non-cardiac problems, such as a heightened risk of cancer.
Nevertheless, previous research has been limited by abstainer bias, which has caused uncertainty surrounding the protective effect of light/moderate alcohol to persist. The researchers of this study also assessed this possibility by conducting a sensitivity analysis that excluded abstainers, which also yielded similar results.
Belgique Dernières Nouvelles, Belgique Actualités
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