Living digital camera: scientists capture light patterns in DNA for image storage NatureComms camera DNA deoxyribonucleicacid technology news research
By Shanet Susan AlexJul 6 2023Reviewed by Lily Ramsey, LLM In a recent article published in Nature communications*, researchers described a technique of capturing two-dimensional light patterns into deoxyribonucleic acid and using high-throughput next-generation sequencing to retrieve recorded images.
The abundance of DNA inside living cells has been regarded as a possible DNA source that biological systems and molecular biology tools can use to encode DNA with data. The team employed a blue light-reactive recombinase system that reacts to the absence or presence of blue light as an external signal and then records that response into DNA by site-specific editing of DNA, effectively digitizing the captured image and enabling deconvolution following DNA sequence retrieval via sequencing.
Results In the current paper, the authors proposed and described a novel approach for direct image capture onto DNA, comparable to the development of a digital camera called BacCam. The researchers added a second wavelength of light to this workflow to expand it beyond the capabilities of a single light wavelength, increasing the amount of information that can be recorded in a single concurrent capture and showcasing the multiplexing characteristics of the system.
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