Researchers determine whether the current and cumulative use of prescription proton pump inhibitors increases the risk of incident dementia.
By Dr. Chinta SidharthanAug 17 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in Neurology, researchers determine whether the current and cumulative use of prescription proton pump inhibitors increases the risk of incident dementia.
The rampant use of PPIs is a serious health concern, as these drugs have been linked to adverse effects such as chronic kidney disease, cardiovascular disease, stroke, and dementia. However, studies documenting the association between the use of PPIs and dementia have produced mixed results. Data collected from the fifth visit of the ARIC study reported common PPI use. Therefore, the present study used Visit 5 as the baseline for assessing PPI use and its impact on incident dementia.
Histamine2 receptor antagonists , which are an alternative treatment option for GERD and other gastroesophageal problems, were examined as a comparator in the secondary analysis. Chronic PPI use increases the risk of dementia Positive associations were observed between the use of PPIs and the risk of dementia; however, these associations were not significant over a median follow-up period of 5.5 years. Nevertheless, the analysis of cumulative PPI use and its association with incident dementia indicated a 33% increased risk of dementia in the later years of life.
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