Ergothioneine levels in the blood could identify elderly persons at risk of developing cognitiveimpairment and dementia NUSingapore
], we tested the mediating effects of WMH and brain atrophy in relating ET to cognitive decline and showed through causal mediation analyses that associations between baseline ET levels and cognitive decline were predominantly mediated by WMH load as well as by the severity of cortical atrophy . We thus postulate that ET deficits are associated with cognitive decline via pathophysiological links with both CeVD as well as neurodegeneration.
Our hypothesis is further supported by the finding that associations between ET deficits and cognitive decline involve multiple cognitive domains, including both cortical function domains, i.e., memory, language, and executive function , as well as subcortical domains that are sensitive to the disruption of frontal-subcortical circuits, i.e., attention and visuomotor speed .
Several limitations of our study should be addressed in future studies. First, although we controlled for the major known or potential confounders, residual confounding remains a possibility due to a lack of comprehensive information on other factors that may affect baseline ET concentrations, such as possible genetic variations and dietary behaviors.
Belgique Dernières Nouvelles, Belgique Actualités
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