Intravenous magnesium sulfate before preterm birth at 30 to 34 weeks of gestation does not improve child survival free of cerebral palsy, according to a study published in the Aug. 15 issue of the Journal of the American Medical Association (JAMA).
Intravenous magnesium sulfate before preterm birth at 30 to 34 weeks of gestation does not improve child survival free of cerebral palsy, according to a study published in the Aug. 15 issue of theinvolving pregnant individuals expected to deliver at 30 to 34 weeks of gestation at 24 Australian and New Zealand hospitals during January 2012 and April 2018; pregnant individuals were randomly assigned to intravenous magnesium sulfate or placebo at 30 to 34 weeks of gestation.
The researchers found no significant difference between death or cerebral palsy at 2 years' corrected age between the groups . There was no difference seen between the groups in components of the primary outcome. Compared with the placebo group, neonates in the magnesium group were less likely to haveand chronic lung disease during the birth hospitalization . There were no serious adverse events reported; adverse events were more likely in those who received magnesium .
"Given a lack of benefit in this current cohort of infants, care must be taken to avoid therapeutic creep and the potential for unintended harm," the authors write.Caroline A. Crowther et al, Prenatal Intravenous Magnesium at 30-34 Weeks' Gestation and Neurodevelopmental Outcomes in Offspring,
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