Magnetic susceptibility as a promising marker for predicting future severity of Parkinson's disease medrxivpreprint parkinsonsdisease PD parkinsons magneticsusceptibility
By Neha MathurJul 18 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study posted to the medRxiv* preprint server, researchers evaluate quantitative magnetic susceptibility mapping , an advanced neuroimaging technique, in detecting quantifiable markers of Parkinson’s disease progression.
Previously, doctors used magnetic-resonance imaging to monitor PD progression; however, this modality is relatively insensitive in detecting the early stages of dementia in PD. To this end, MRI relies on measuring the volume or thickness of cortical regions alone, whereas other measures that are sensitive to changes in brain tissue composition, such as brain tissue iron, are more effective for detecting and tracking neurodegeneration associated with PD.
At the study baseline, 107 patients with early to mid-stage PD between 49 and 80 years of age who were diagnosed within the past 10 years were included. The study enrollment began in October 2017 and ended in December 2018. In addition, 37 age-matched controls were recruited to participate, including unaffected patient spouses.
Post-hoc ROI analyses were also performed to determine any interactions between motor and cognitive severity and signed susceptibility in PD patients. The ROIs for this analysis included substantia nigra pars compacta and pars reticulata , red nucleus, caudate nucleus, putamen, globus pallidus, hippocampus, nucleus basalis of Meynert , insular cortex, lateral, medial orbitofrontal cortex, and dentate nucleus.
Relationship between increased absolute magnetic susceptibility and declining cognitive ability over the Parkinson’s disease course, in a whole brain analysis. A. Association between baseline susceptibility and composite cognitive score at baseline, adjusted for age at baseline and sex. B. Association between baseline susceptibility and composite cognitive score at 3-year follow-up, adjusted for age at baseline, sex and time between scans. C.
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