Majordepressivedisorder linked to interplay of gutmicrobiome and blood metabolome JAMAPsych
What are the metabolic signatures of major depressive disorder , what direction do they take, and how does the host gut microbiome contribute to these signatures?In this cohort study, metabolites in the energy and lipid metabolism processes were associated with MDD. Changes in lipid metabolism were consistent with the gut dysbiosis observed in individuals with MDD.
Publicly available summary statistics from a 2019 genome-wide association study of depression were used for the mendelian randomization . Summary statistics for the metabolites were obtained from OpenGWAS in MRbase . To evaluate the interplay of the metabolome and the gut microbiome in the pathogenesis of depression, metabolic signatures of the gut microbiome were obtained from a 2019 study performed in Dutch cohorts. Data were analyzed from March to December 2021.
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