Microniches of intratumoral microbiota impact spatial and cellular heterogeneity in cancer natureportfolio fredhutch Microbiota Cancer CellularHeterogeneity
By Neha MathurNov 22 2022Reviewed by Aimee Molineux In a recent article published in Nature, researchers mapped spatial, cellular, and molecular interactions of host and tumor-associated bacteria within the tumor microenvironment . They used in situ spatial-profiling technologies and single-cell ribonucleic acid sequencing , focusing on gastrointestinal cancers, in particular, oral squamous cell carcinoma and colorectal cancer .
About the study In the present study, researchers first assessed the composition of the intratumoral microbiota at the phylum and genus levels. Next, they visually confirmed the heterogeneous spatial distribution of the identified bacterial communities, including Fusobacterium nucleatum. To this end, they performed 16S ribosomal RNA gene sequencing on 44 tissue pieces from the tumors of 11 patients with CRC.
Study findings Related StoriesRNAscope-FISH identified bacterial transcripts in 46% and 28% of the capture spots within CRC and OSCC tumors, respectively. Bacterial genera identified per capture spot ranged from one to 42 and one to 31, with a median of eight and two in the OSCC and CRC tumors, respectively. In the OSCC tumor, the UMI metric identified Parvimonas, Peptoniphilus, and Fusobacterium as the most dominant bacterial genera.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Researchers identify a novel RSV variant associated with prolonged infectionResearchers identify a novel RSV variant associated with prolonged infection Respiratory Syncytial Virus RSV Infectious Disease Pathogen Respiratory JIDJournal epfl EmoryUniversity PittTweet VanderbiltU
Lire la suite »
Researchers find an abundance of microplastics in placentas and meconium samplesThe embryonic and fetal periods of life are vulnerable to impact by harmful chemicals in the environment. These include microplastics (MPs), which have been found in many living organisms and tissues, stemming from the environmental degradation of waste plastics. Using placental tissue and meconium samples, a new study examines the links between exposure to MPs in pregnancy and microbiomes.
Lire la suite »
Mindfulness found to be associated with emotional resilience in children during the COVID-19 pandemicMindfulness found to be associated with emotional resilience in children during the COVID-19 pandemic medrxivpreprint MIT Mindfulness COVID19 Pandemic SARSCoV2 EmotionalResilience
Lire la suite »
The biological properties of the SARS-CoV-2 E protein in the context of HIV-1The biological properties of the SARS-CoV-2 E protein in the context of HIV-1 UnivOfKansas KUMedCenter SARSCoV2 COVID19 coronavirus covid HIV
Lire la suite »
Approved and developing passive and active immunizations against respiratory syncytial virus in childhood and pregnancyApproved and developing passive and active immunizations against respiratory syncytial virus in childhood and pregnancy PUCRS vaccine vaccination virus virology disease respiratory
Lire la suite »
Kiwira virus: a new bat-borne hantavirus detected in AfricaKiwira virus: a new bat-borne hantavirus detected in Africa Hantavirus Virus Bats Africa VirusesMDPI HumboldtUni rki_de NM_AIST inrb_kinshasa ComeniusUni
Lire la suite »