Mechanism resembling aging and cancer found in a Finnish mitochondrialdisease helsinkiuni NatureComms
variant, were considered phenotypically WT. The analyses included both sexes unless otherwise stated. Where appropriate, the figures show the data separately for both sexes. All mice were on C57BL/6JCrl nuclear genomic background and received water and chow . The animal facilities of University of Helsinki housed the mice in temperature-controlled individually-ventilated cages under 12-h light/dark cycle.
. Briefly, we utilized here samples from mice fed control chow or ketogenic diet from weaning until approximately P45.For the cloning of the Omomyc rAAV construct, a human c-MYC fragment encoding amino acids 350–439 was PCR-amplified , cloned into a pBluescript vector, and the four Omomyc mutations introduced by inverse PCR mutagenesis. After sequencing, the fragment was subcloned into the pAAV2.LSP1 vector .
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