Mpox virus from Clade 2b is the least virulent strain according to new study biorxivpreprint NIH mpox Clade2b VirulentStrain Strain
By Dr. Chinta SidharthanDec 5 2022Reviewed by Aimee Molineux In a recent study posted to the bioRxiv* preprint server, researchers used the CAST/EiJ mouse model to test whether genetic differences between clades 1, 2a, and 2b of the mpox virus contribute to changes in transmission and virulence of the disease.
About the study In the present study, the researchers identified a suitable small animal model that can be used to study the differences in virulence and transmission of mpox by screening 38 inbred mouse strains for vulnerability to the mpox virus. Identifying the appropriate animal model system presented a challenge since the animal must be inbred, susceptible to mpox, and can be bred in captivity.
Results Genetics & Genomics eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The results reported that in CAST/EiJ mice, the virulence of the mpox virus from clade 1 was 1000 times more than that of the clade 2a mpox virus. Infections with 103 plaque-forming units of clade 1 mpox virus resulted in 20% weight loss in all the mice and one death.
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