Research led by the Université Paris Cité, CNRS, France, has investigated factors driving variability in diverse immune responses to SARS-CoV-2.
In a paper,"Dissecting human population variation in single-cell responses to SARS-CoV-2," the team used single-cell RNA sequencing to analyzefrom diverse populations, comparing responses to SARS-CoV-2 against factors like genetics, age, sex, and comorbidities.
As an environmental factor, exposure to a virus can be a local or regional occurrence. Without knowledge of these exposures, immune response differences could be correlated to ancestry. The authors warn that this could lead to overestimating the effects of genetic ancestry on immune response variation.
The researchers also identified previously unreported signals of Neanderthal introgression affecting immunity phenotypes. For example, a gene variant that decreases post-translational modification responses to SARS-CoV-2 and IA was found in 38% of Europeans and 22% of East Asians.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Does convalescent serum treatment lower mortality in SARS-CoV-2-infected individuals?Does convalescent serum treatment lower mortality in SARS-CoV-2-infected individuals? SciReports convalescent serum covid COVID19 SARSCoV2
Lire la suite »
The protective effect of previous infections and vaccinations on SARS-CoV-2 Omicron infectionThe protective effect of previous infections and vaccinations on SARS-CoV-2 Omicron infection NatureComms rivm infections infection vaccine vaccination SARSCoV2 Omicron
Lire la suite »
Dissecting human population variation in single-cell responses to SARS-CoV-2 - NaturePopulation differences in immune responses to SARS-CoV-2 can be explained by environmental exposures, but also by local adaptation acting through genetic variants acquired after admixture with archaic hominin forms.
Lire la suite »
Evaluating medical research using a new “diversity index” could promote better health outcomesScientific journals and research papers are evaluated by a metric known as their 'impact factor,' which is based on how many times a given paper is cited by other papers.
Lire la suite »
Hebden Bridge man with incurable cancer in 96-mile charity walkDarren Walker is raising money to fund research into pseudomyxoma peritonei (PMP).
Lire la suite »
IBM describes analog AI chip that might displace GPUsPower-sipper still in the research stage, but findings are interesting
Lire la suite »