New biomarker strategy devised to screen for, diagnose deadly heart complication from cancer treatment

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New biomarker strategy devised to screen for, diagnose deadly heart complication from cancer treatment
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New biomarker strategy devised to screen for, diagnose deadly heart complication from cancer treatment umich

, investigators found that nearly all patients with cancer who were diagnosed with myocarditis after being treated withinhibitors have revolutionized the treatment of various cancers, patients who develop the rare complication of myocarditis often present late with at least a 50% chance of death," said Salim Hayek, M.D., senior author of the study and medical director of the University of Michigan Health Frankel Cardiovascular Center Clinics.

Researchers analyzed more than 2,600 patients with cancer treated with immune checkpoint inhibitors at University of Michigan Health between June 2014 and Dec. 2021. The vast majority of patients diagnosed with ICI myocarditis also had early signs of muscle injury and, even prior to hospitalization. Of these patients, 95% had at least three elevated biomarkers, compared to just 5% of patients without myocarditis.

"It makes sense that myocarditis related to immune checkpoint inhibitors does not occur in isolation, given a raging immune system is expected to affect several organs and particularly the muscles," said co-author Joe-Elie Salem, M.D. Ph.D., professor of medicine at Sorbonne Université in Paris and a leading expert in the field of ICI myocarditis.

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