New clinical tool for clonal hematopoiesis identifies patients at high risk for bloodcancer danafarber
Now, a new clinical tool developed by a team of researchers led by the Dana-Farber Cancer Institute pinpoints which CH patients are at highest risk for cancer progression. Their work was reported at the"We've been able to detect clonal hematopoiesis in patients for years now," said Dana-Farber hematologist-oncologist and lead author Lachelle D. Weeks, MD, Ph.D., who presented the study at ASH.
Weeks and her colleagues, led by senior author Benjamin Ebert, MD, Ph.D., chair of medical oncology at Dana-Farber, analyzed data from nearly 200,000 healthy participants in the UK Biobank. They examined exome sequencing data to determine specificassociated with CH and combined genetic data with other demographic and laboratory parameters.
From this information, they identified several measures that were highly predictive of blood cancer risk in CH patients. These measures include a patient's age; the type and number of genetic mutations present in ; the fraction of cells in the blood with the CH mutation; low blood counts; and factors related to red blood cell volume., creating a tool that calculates a clonal hematopoiesis risk score , which predicts an individual's future risk of developing blood cancer. CHRS values define three distinct groups of patients according to the likelihood of cancer progression—low risk ; intermediate risk ; and high risk .
While the 10-year risk of blood cancer is less than 1% in the low-risk group, the risk of developing a blood cancer such as
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