New findings on how to avert excessive weightloss from COVID-19
by targeting the blood vessels in the fat tissues," says Yihai Cao, professor at the Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, and the study's corresponding author.
The researchers examined how different types of fat, including brown fat and visceral and subcutaneous white fat, reacted when exposed to SARS-CoV-2 and how it impacted weight in mice and hamsters. They found that the animals lost significant amounts of weight in four days and that this weight loss was preceded by the activation of brown fat and the browning of both types of white fat. These fat tissues also contained more microvessels and high levels of a signaling protein calledThe researchers observed the same mechanisms in human tissue samples from four patients who died of COVID-19, suggesting the findings could be clinically relevant for humans.
, a so-called antiangiogenic drug, the animals recovered most of their lost weight and their fat tissues exhibited fewer microvessels. "Antiangiogenic drugs are currently used in the clinic to treat various types of cancers," Yihai Cao says."It's possible these drugs could also be helpful in treating COVID-19-related problems such as excessive weight loss and metabolic changes, thus improving the quality of life and survival for these patients. Of course, we will need more research to validate if our preclinical findings also hold up in human trials.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
COVID-19 vaccines may reduce long-COVID symptomsA new study describes the effectiveness of coronavirus disease 2019 (COVID-19) vaccines in reducing long-COVID symptoms.
Lire la suite »
Comprehensive new review of COVID-19 vaccines shows they are effectiveA comprehensive review of all the evidence available from randomized controlled trials of COVID 19 vaccines up to November 2021 has concluded that most protect against infection and severe or critical illness caused by the virus.
Lire la suite »
FIA to drop F1 COVID vaccination requirement for 2023The FIA has announced that it will relax Formula 1’s COVID-19 protocols for the 2023 season, including a requirement for those in the paddock to be vaccinated.
Lire la suite »
FIA to drop F1 COVID vaccination requirement for 2023The FIA has announced that it will relax Formula 1’s COVID-19 protocols for the 2023 season, including a requirement for those in the paddock to be vaccinated.
Lire la suite »
China risks ‘wave of infections’ after relaxing zero-Covid policy, warns Fauci\n\t\t\tKeep abreast of significant corporate, financial and political developments around the world.\n\t\t\tStay informed and spot emerging risks and opportunities with independent global reporting, expert\n\t\t\tcommentary and analysis you can trust.\n\t\t
Lire la suite »