New insights into severe obesity genetics: Evidence from adults seeking treatment reveals intriguing oligogenic patterns medrxivpreprint imperialcollege Bruneluni genetcis obesity health disease
By Dr. Priyom Bose, Ph.D.Aug 14 2023Reviewed by Benedette Cuffari, M.Sc. Obesity is a complex disorder that is dependent on environmental and genetic factors. Severe obesity, which is otherwise known as class III obesity, is a chronic condition that increases the risk of mortality and morbidity.
*Important notice: medRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information. Although the effect of oligogenic inheritance has been established for many diseases, there is a lack of evidence regarding its influence on severe obesity.
The newly developed genotyping array was applied to 1,714 unrelated adults seeking treatment for severe obesity. These participants were recruited between 2011 and 2021 for the Personalised Medicine for Morbid Obesity National Health Service -registered portfolio trial. The results of the genetic screen were compared with the clinical cohort containing 50,000 whole exome sequencing datasets from the U.K. Biobank.
As compared to previous studies, the current study observed a higher prevalence of possible Mendelian obesity. This disparity in results could be due to other studies considering variants from fewer genes. The findings of the custom-designed rare-variant genotyping array were compared with the WES dataset of the UKB cohort, which revealed that the overall prevalence of qualifying variants was not significantly different. This finding was surprising, as the UKB cohort represented healthy individuals.
Belgique Dernières Nouvelles, Belgique Actualités
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