New Nanoparticle Breakthrough to Treat Cancer Photoimmunotherapy nanoparticles biotechnology
One of the most notable applications of LMs is photothermal therapy against cancer, in which functional LM nanoparticles transform light energy to heat energy, thus killing cancerous cells. LM-based phototherapy is better than traditional cancer therapy due to its high repeatability, specificity, and few side effects.
We believe that the convergence of nano-immuno engineering and LM technology could provide a promising modality to trigger ideal immune responses for advancing cancer immunotherapy. In this study, we report light-activatable multifunctional LM nanoparticles with immunostimulants to combine photothermal therapy with immunotherapy. Advanced Materials eBook Compilation of the top interviews, articles, and news in the last year.
These study outcomes verified that PEG-IMIQ-LM nanoparticle was a strong and stable photothermal drug carrier, which is ideal for immunotherapy. Fluorescent microscopy fitted with a laser beam illustrated that the LM particle exhibited strong fluorescence at several NIR wavelengths and instantly ruined the Colon26 cells.
The modified particle, Anti-PD-L1‒PEG–ICG–IMIQ–LM, was dispersed efficiently with considerable fluorescence. With rising time post-irradiation, the tumor surface temperature went up linearly, indicative of the antitumor effect of the nanoparticle.
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