New sensor uses MRI to detect light deep in the brain MIT natBME
This type of sensor could be used to map light emitted by optical fibers implanted in the brain, such as the fibers used to stimulate neurons during optogenetic experiments. With further development, it could also prove useful for monitoring patients who receive light-based therapies for cancer, the researchers say.
To overcome that limitation, Jasanoff and his students decided to design a sensor that could transform light into a magnetic signal. The particles, which the researchers called liposomal nanoparticle reporters , can switch from permeable to impermeable depending on the type of light they're exposed to. In this study, the researchers created particles that become leaky when exposed to ultraviolet light, and then become impermeable again when exposed to blue light. The researchers also showed that the particles could respond to other wavelengths of light.
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