New study unveils epigenetic 'traffic lights' controlling stop and go for gene activity icrnews nature
Scientists at The Institute of Cancer Research, London, reveal how a key epigenetic signal called H3K4me3—determines when and how DNA should be read and translated into proteins within our cells.
how the process of gene expression—decoding DNA into functional proteins used by our body—is regulatedThe long-term hope is that this new understanding could lead to a new class of cancer treatments that target epigenetic 'traffic lights' to block the activity of genes that may be fueling cancer. The team found that H3K4me3 acts like a traffic light at a busy intersection. By regulating the flow of RNA polymerase II—a protein complex that reads and decodes DNA—H3K4me3 determines when gene expression should start and the speed at which it runs.
Study leader Professor Kristian Helin, Chief Executive of The Institute of Cancer Research, London, and a world leader in the study of epigenetics, said,"Our study offers a fundamental new understanding of epigenetics, a very exciting and still largely underexplored area of cancer research. We have solved a 20-year-old puzzle by discovering how a well-known epigenetic modification controls gene expression.
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