Even early forms of liverdisease affect heart health, new study finds
Results from post hoc analyses of data from statin trials suggested that cardiovascular outcomes may improve more in patients with mildly to moderately elevated aminotransferase levels compared with individuals with normal liver tests, in association with improved aminotransferase levels in the majority of individuals.
Patients with elevated plasma activities of ALT and AST warrant evaluation for causes of aminotransferase elevations and consideration of assessment for hepatic steatosis, particularly when risk factors for NAFLD are present. Patients with normal ALT and AST levels can be considered for evaluation for hepatic steatosis when multiple risk factors are present, particularly type 2 diabetes.
Vibration-controlled transient elastography is an ultrasound-based method for noninvasive assessment of elasticity of the liver that is approved by the US Food and Drug Administration for assessing liver disease in children and adults.This imaging modality is becoming more readily available for clinical use and is efficacious for assessing steatosis and estimating the extent of fibrosis.
Liver biopsy is the definitive test for diagnosis of more advanced stages of NAFLD that include hepatic steatosis, NASH, and cirrhosis, but it is an expensive procedure that is associated with risk of morbidity and very low risk of death.Liver biopsy is not required in many patients but may be considered when the risk of advanced NASH is sufficiently elevated to warrant liver biopsy or when liver biopsy is required to exclude other causes of liver disease.
Belgique Dernières Nouvelles, Belgique Actualités
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