New noninvasive optical imaging approach for monitoring brainhealth in traumaticbraininjury patients umich
]. The left two graphs are of the intensity of the reference arm and the sample arm, and using the algorithms, the calculated outputs are the HbO, HbR, and the CCO concentration. In summary, the SCISCCO hardware and software were integrated into a stable, convenient-to-operate cart system, and this system was transported to Northwestern University for animal testing as described below.
the expected behavior of CCO, HbO, and HbR in various physiological states. The status column indicates whether or not our preliminary findings verified these results to date.An exemplary data set measured by the SCISCCO system with the swine undergoing a pREBOA procedure is illustrated in. The red curve corresponds to the HbO concentration, the blue curve corresponds to the HbR concentration, and the green curve corresponds to the CCO concentration.
When the REBOA was applied , oxygenated blood was prevented from going to the abdomen and lower extremities, and more oxygenated blood was then shunted to the brain. There was a 10-min period of complete aortic occlusion that was followed by the onset of pREBOA, which was reflected in the increase in HbO at occlusion that then dipped and recovered throughout the intervention phase.
During this preliminary experiment, the data collected by the SCISCCO system was also compared with other independent instruments. For example,a shows the oxygenated hemoglobin measured with the SCISCCO system compared with the oxygenation measured using an arterial blood gas instrument . There was reasonable agreement between the two measurements, and the SCISCCO system provided a finer temporal resolution.
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