The effectiveness of virus-like particle (VLP)-based vaccines targeting epitopes in the low-density lipoprotein (LDL) receptor.
By Tarun Sai LomteOct 2 2023Reviewed by Lily Ramsey, LLM In a recent study published in npj Vaccines, researchers evaluated the effectiveness of virus-like particle -based vaccines targeting epitopes in the low-density lipoprotein receptor domain of proprotein convertase subtilisin/kexin type 9 .
LDL-R removes LDL-C from circulation and is recycled to the plasma membrane once LDL-C is metabolized. PCSK9 is a secretory protein that inhibits and mediates the lysosomal degradation of LDL-R. Mice, heterozygous for Ldlrtm1Her mutation, that express high serum cholesterol but low function LDL-R were used to study vaccine effects. A small subset of LDLR+/- mice received three doses of 5 μg mPCSK9153-163 VLPs, mPCSK9207-223 VLPs, or wild-type Qβ VLPs . Additionally, a large subset of mice received the bivalent vaccine comprising 5 μg each of mPCSK9153-163 and mPCSK9207-223 VLPs.
Livers were harvested from bivalent vaccine recipients and controls to measure LDL-R. LDL-R expression increased by about 50% in bivalent vaccine recipients compared to controls. The macaques also received simvastatin from days 77 to 105 to evaluate if stains had synergistic effects. Additionally, they were boosted four weeks before the necropsy.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Mexico’s gangs could be the country’s fifth-biggest employerA recent paper suggests a novel way to curb their power
Lire la suite »
Mogrify extends Series A financing to $46 million USDMogrify Limited (Mogrify ® ), a biopharmaceutical company transforming the lives of patients through a novel class of in vivo reprogramming therapies, announced today an additional $10 million USD...
Lire la suite »
Preterm birth risk highlighted in Stanford-led study on sleep and activity during pregnancyResearchers developed series2signal, a novel, state-of-the-art prediction model that used wearable data from pregnant women to predict gestational age as a proxy for the progression of pregnancy and the likelihood of poor pregnancy outcomes, especially preterm birth, based on wearable-detected changes in maternal sleep quality and physical activity levels.
Lire la suite »
The Amber Menhir by Jonathan N. Pruitt is a gripping dark fantasy full of jeopardy, mystery, and deceptionAs American author Jonathan N. Pruitt puts it, his new dark fantasy novel The Amber Menhir — book one of The Shadows of the Monolith series — could be described as a mix of Harry Potter and Game of Thrones. Set on a world destined for destruction, it throws three young friends into a murky magical institution regarded as society’s saviour, but secretly a viper’s pit of murderous ambitions and rivalries.
Lire la suite »
Breastfeeding is associated with lower levels of body fat at the age of nineNew research presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2–6 Oct) has linked infant formula and the early introduction of fizzy drinks with higher levels of body fat later in childhood.
Lire la suite »