Novel workflow reveals untapped diversity in fatty acid isomers across all life forms NatureComms fattyacid isomers massspectrometry liposome
By Pooja Toshniwal PahariaJul 6 2023Reviewed by Lily Ramsey, LLM In a recent study published in the Nature Communications Journal, researchers introduced a comprehensive workflow to discover unsaturated fatty acids through coupling liquid chromatography and mass spectrometry with gas-phase ozonolysis of double bonds.
About the study In the present study, researchers devised an LC-OzID-MS-based approach for de novo, library-independent detection of fatty acid isomers, including mathematically prepared target lists. Direct infusion ESI-mass spectrometry was performed to determine the groups of fatty acid molecules and, in combination with their relative abundance, provided estimates of fatty acid quantities in absolute terms.
Among vernix caseosa samples, the analysis showed an unusual variety of double-type chemical bond configurations, including 18, 116, and 32 straight chain-type saturated, monounsaturated, and polyunsaturated fatty acids, respectively. Of importance, the workflow’s dynamic range and selectivity revealed features corresponding to double-type chemical bond regioisomers, despite being partially determined by chromatography, as verified by the data-dependent acquisition .
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