Use of an older class of type 2 diabetes drugs called glitazones, also known as thiazolidinediones or TZDs for short, is linked to a 22% reduced risk of dementia, reveals a long term study published in the open access journal BMJ Open Diabetes Research & Care.
with those treated with metformin alone. They drew on the electronic health records of 559,106 people diagnosed with type 2 diabetes from the national Veteran Affairs Health System, spanning the period from January 2000 to December 2019. and given a first prescription of metformin, or a sulfonylurea , or a TZD between January 2001 and December 2017 were included in the study. Their health was tracked for an average of nearly 8 years.
Specifically, it was associated with an 11% lower risk of Alzheimer's disease and a 57% lower risk of vascular dementia. Given that vascular diseases increase the risk of Alzheimer's disease, TZDs may also help to reduce dementia and Alzheimer's disease in part through their favorable effects on the vascular system, say the researchers.
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