Omicron has higher risk of in-hospital mortality compared to influenza Hospital Influenza Mortality Omicron Coronavirus Disease COVID JAMANetworkOpen UniLuzern unibern UNIGEnews ChariteBerlin
Study: Hospital Outcomes of Community-Acquired SARS-CoV-2 Omicron Variant Infection Compared With Influenza Infection in Switzerland. Image Credit: NIAID
The systems that monitor seasonal influenza infections in Switzerland reported that the influenza subtype A was responsible for 94% of all the sequenced influenza cases in 2022. Influenza and SARS-CoV-2 are both respiratory viruses that cause infections in the upper respiratory tract, and comparisons between the hospital outcomes of influenza and SARS-CoV-2 infections can be used to assess the disease burden of COVID-19.
The primary outcome was all-cause mortality, while the secondary outcome was intensive care unit admission. Additional endpoints such as pneumonia, acute respiratory distress, need for ventilation, cardiovascular, neurological, or renal complications, antibiotic treatment, and the duration of hospitalization were also analyzed. Cox regression analysis was performed with weights for sex, age, and hospital treatment centers.
A total of 5212 patients were included in the study, out of which 3066 were admitted for SARS-CoV-2 Omicron infections, and 2146 patients were admitted with influenza A or B infections. Patients with SARS-CoV-2 Omicron infections were younger than those with influenza infections. Of the 3,066 SARS-CoV-2 Omicron infection patients, 7% of the patients died in the hospital, while 4.4% of the influenza patients died during hospitalization.
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