A Review published in Molecular Neurodegenation summarizes the pathophysiology of cerebral small vessel disease in Alzheimer’s and discusses the probable etiological pathways to define its potential diagnostic and therapeutic targets.
As contributions of VCID to age-related cognitive decline have been increasingly recognized, greater understanding of cSVD pathophysiology and etiology is desired to develop novel diagnostic and therapeutic strategies for the disease. Given that hypertension, smoking, and diabetes are strong risk factors for cSVD, it is reasonable to consider cSVD as a primary phenotype of metabolic syndrome in the brain.
In addition, cSVD might be causatively and consequently involved in AD pathogenesis as CAA is a common type of cSVD. While cSVD and AD frequently coexist in the elderly, future studies should further define how ameliorating cSVD phenotypes influence the onset and development of AD.
Belgique Dernières Nouvelles, Belgique Actualités
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Small plane crashes trying to land on Martha's Vineyard with 2 people onboardA small plane crashed while trying to land at the airport on Martha’s Vineyard Saturday, after the pilot became incapacitated due to a medical episode onboard. West Tisbury police said the Piper Meridian Turbo Prop 6 seat plane was reported to have crashed at 3:12 p.m. at the Martha’s Vineyard Airport. The Federal Aviation Administration confirmed two people were onboard…
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