A Ludwig Cancer Research study has shown that combining adoptive T cell therapy (ACT) with an innovative, personalized cancer vaccine under development at the Lausanne Branch of the Ludwig Institute for Cancer Research can benefit patients with late-stage, drug-resistant ovarian cancer.
with ACT yielded control of the disease within three months in 12 of 17 patients. The treatment was also found to be safe and relatively well tolerated.
"It was also exciting to be able to suggest, through sophisticated immunologic analysis, the mechanisms underlying treatment efficacy," said Harari. To make the vaccine, researchers first coax precursor immune cells isolated from patients to turn into, which present cancer antigens to killer T cells to direct and activate their anti-tumor responses.
Patients additionally receive low doses of chemotherapy to clear existing T cells from lymph nodes and make room for the newly infused T cells. A component of the chemotherapy, cyclophosphamide, also suppresses regulatory T cells, which inhibit killer T cell responses.
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