The impacts of physical activity on the neuronal formation and prevent age-related cognitive decay.
By Pooja Toshniwal PahariaAug 22 2023Reviewed by Lily Ramsey, LLM In a recent study published in Nature Communications, researchers investigated whether platelet-released exerkines such as C-X-C motif ligand 4 or platelet factor 4 can simulate the impacts of physical activity on the neuronal formation and prevent age-related cognitive decay.
About the study In the present study, researchers evaluated the impact of CXCL4 on cognition and aging using a neurogenesis ablation model of transgenic and aged mice. To determine whether cxcl4 is essential for preserving adult hippocampus neurogenesis, CXCL4 knockout animals with platelets devoid of CXCL4 messenger ribonucleic acid were used.
Platelet responses to short- and long-term exercise were assessed by proteomic screening on platelets from aged mice after a 4.0-week run. New object localization tasks, contextual fear conditioning, and active place avoidance tests were performed. Increasing serological CXCL4 levels in young mice did not lead to cell proliferation, or quiescent neural stem cell recruitment since there were no significant variations in the proportion of CXCL4-treated cells in various cell cycle stages such as gap 2 , mitosis and synthesis stages.
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