Prevalence and severity of liver enzyme alterations in COVID-19 and association with patient-centered outcomes medrxivpreprint georgeinstitute UniofOxford Univ_Lorraine COVID19 coronavirus covid liver enzyme
By Tarun Sai LomteNov 15 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to medRxiv*, researchers examined the prevalence of changes in liver enzymes in coronavirus disease 2019 .
About the study The present study evaluated the prevalence and severity of liver enzyme changes in patients hospitalized with COVID-19 using the ISARIC dataset. All hospitalized patients from January 30, 2021, to September 21, 2021, with suspected/confirmed infection with severe acute respiratory syndrome coronavirus 2 were included in the primary analysis. Patients lacking data on clinical outcomes or liver enzyme tests were excluded.
Related StoriesIn addition, the researchers evaluated the associations between baseline liver enzymes and complications developed in the hospital. Logistic regression was used to determine the relationship between exposure and outcome variables. Sensitivity analysis was performed by including patients with laboratory-confirmed SARS-CoV-2 infection.
Oxygen supplementation was required for 48%, 70.3%, and 75.9% of stage 0, I, and II patients, respectively. Invasive ventilation was required by 9.8% of stage 0 patients, 21.3% of stage I patients, and 27% of stage II patients. The median LoS in the hospital was nine days for stage 0 and II patients and eight days for stage I patients.
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