Print your own vaccine: automatic printing of microneedle patch COVID-19 mRNA vaccines NatureBiotech MIT harvardmed ragoninstitute vaccine vaccines vaccination mRNA COVID19 coronavirus covid SARSCoV2
By Pooja Toshniwal PahariaApr 26 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in Nature Biotechnology, researchers reported on the automatic printing of microneedle patch severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid vaccines.
About the study In the present study, researchers used microneedle vaccine printing to fabricate thermostable COVID-19 mRNA vaccines in an LNP vehicle. Thermogravimetric analysis was performed to evaluate drying time, and drying rates for various drying strategies were compared by linear regression modeling. The drop area and MNP coverage of the polymer solution were also evaluated. MNPs on an ultrathin acrylic backing, produced using the standalone device, were imaged using scanning electron microscopy . The throughput of the microneedle patch was assessed in terms of tray lengths and the duration required for drying.
Results The MNPs showed a ≥6.0 month-shelf stability at room temperatures. Vaccine loading efficiency and MNP dissolution indicated that efficacious, microgram-level dosages of LNP-encapsulated mRNA could be administered by an MNP. Vaccinations in mice with SARS-CoV-2 spike RBD stimulated durable immunological responses comparable to those induced by IM administration. The SEM analysis showed images of MNPs with conical and pyramid geometries.
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