Research shows people with latent tuberculosis infection are more prone to inflammation UofCincy
]. Our findings suggest that pro-inflammatory monocytes may be found through different stages of the TB spectrum, including LTBI. However, monocyte alterations seem more subtle in LTBI and may not be equally present within the entire LTBI continuum.
Our study had limitations. Our sample size was limited to detecting small differences on monocyte markers between study groups. Nevertheless, to our knowledge, our work represents the largest study to date to profile monocyte subsets and their pro-inflammatory responses in LTBI. Furthermore, we were able to find distinct alterations in total and subset monocytes. LPS may induce downregulation of CD16, which could pose a challenge to identify CD16monocyte subsets post-LPS.
In conclusion, individuals with LTBI exhibit distinct pro-inflammatory alterations of their monocytes, including increased CX3CR1 and CD36 expression as well as production of pro-inflammatory cytokines. These findings support the capacity ofinfection to alter the integrity of immune responses. Whether these monocyte alterations contribute to cardiovascular disease pathogenesis warrants further investigation.online.
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