Neoadjuvant concurrent chemoradiotherapy affects the diversity, abundance, and composition of the gut microbiome in patients with locally advanced rectal cancer, finds a study published in the Journal of Translational Medicine.
e, f). These findings suggest potential correlations between longitudinal changes in CSTs and effectiveness of therapy.a
, Nonmetric multidimensional scaling analysis of amplicon sequencing variants of all samples, indicating that all samples could be assigned to one of three community state types .Bacterial CSTs over time in individual patients before, during and after nCCRT. Patients were categorized in terms of response .Overview of CST proportions in patients with good response to nCCRT and poor response to nCCRT . * 0.2– ≤ − 0.2. The two grey circles indicate correlation coefficient radii at 0.5 and 1.0.
To further investigate the relationship between bacterial diversity, immune panel, and treatment response, candidate microbes and immune cells and immunomodulatory proteins were selected to construct a predictive LASSO model at the before-nCCRT and during-nCCRT timepoints.
Belgique Dernières Nouvelles, Belgique Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Recent advances in targeted therapies in acute myeloid leukemia - Journal of Hematology & OncologyAcute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival for younger patients over the last several decades has improved nearly sixfold with the optimization of intensive induction chemotherapy and allogeneic stem cell transplantation (alloHSCT), this effect has been largely mitigated in older and less fit patients as well as those with adverse-risk disease characteristics. However, the last 10 years has been marked by major advances in the molecular profiling of AML characterized by a deeper understanding of disease pathobiology and therapeutic vulnerabilities. In this regard, the classification of AML subtypes has recently evolved from a morphologic to a molecular and genetic basis, reflected by recent updates from the World Health Organization and the new International Consensus Classification system. After years of stagnation in new drug approvals for AML, there has been a rapid expansion of the armamentarium against this disease since 2017. Low-intensity induction therapy with hypomethylating agents and venetoclax has substantially improved outcomes, including in those previously considered to have a poor prognosis. Furthermore, targeted oral therapies against driver mutations in AML have been added to the repertoire. But with an accelerated increase in treatment options, several questions arise such as how to best sequence therapy, how to combine therapies, and if there is a role for maintenance therapy in those who achieve remission and cannot undergo alloHSCT. Moreover, certain subtypes of AML, such as those with TP53 mutations, still have dismal outcomes despite these recent advances, underscoring an ongoing unmet need and opportunity for translational advances. In this review, we will discuss recent updates in the classification and risk stratification of AML, explore the literature regarding low-intensity and novel oral combination therapies, and briefly highlight investigative agents currently in early clinical development
Lire la suite »
Wall Street Journal reporter Evan Gershkovich arrested in Russia for alleged spyingEvan Gershkovich is the first reporter for an American news outlet to be arrested on espionage charges in Russia since the Cold War and could face up to 20 years in jail if found guilty.
Lire la suite »
Prolactin and oxytocin: potential targets for migraine treatment - The Journal of Headache and PainMigraine is a severe neurovascular disorder of which the pathophysiology is not yet fully understood. Besides the role of inflammatory mediators that interact with the trigeminovascular system, cyclic fluctuations in sex steroid hormones are involved in the sex dimorphism of migraine attacks. In addition, the pituitary-derived hormone prolactin and the hypothalamic neuropeptide oxytocin have been reported to play a modulating role in migraine and contribute to its sex-dependent differences. The current narrative review explores the relationship between these two hormones and the pathophysiology of migraine. We describe the physiological role of prolactin and oxytocin, its relationship to migraine and pain, and potential therapies targeting these hormones or their receptors.In summary, oxytocin and prolactin are involved in nociception in opposite ways. Both operate at peripheral and central levels, however, prolactin has a pronociceptive effect, while oxytocin appears to have an antinociceptive effect. Therefore, migraine treatment targeting prolactin should aim to block its effects using prolactin receptor antagonists or monoclonal antibodies specifically acting at migraine-pain related structures. This action should be local in order to avoid a decrease in prolactin levels throughout the body and associated adverse effects. In contrast, treatment targeting oxytocin should enhance its signalling and antinociceptive effects, for example using intranasal administration of oxytocin, or possibly other oxytocin receptor agonists. Interestingly, the prolactin receptor and oxytocin receptor are co-localized with estrogen receptors as well as calcitonin gene-related peptide and its receptor, providing a positive perspective on the possibilities for an adequate pharmacological treatment of these nociceptive pathways. Nevertheless, many questions remain to be answered. More particularly, there is insufficient data on the role of sex hormones in men and the correct dosing acc
Lire la suite »
The Kremlin escalates its war on truthThe arrest of an American journalist shows how far Vladimir Putin will go to hide the reality of his war in Ukraine
Lire la suite »
Buyers forced to withdraw from sales at Glasgow development 'dogged by controversy'Prospective buyers have been forced to withdraw from a landmark Glasgow flat development 'dogged by controversy' due to unexpected delays…
Lire la suite »