Raspberry-Like Nanoadjuvants Help Target Deep Tissue Tumors nanomedicine nanomaterials nanobiotechnology cancer cancerresearch AdvSciNews
By Bhavna KavetiSep 13 2022Reviewed by Susha Cheriyedath, M.Sc. Cancer photo-immunotherapy is a promising strategy that triggers the release of hostile signals on irradiating with an appropriate dose of laser to unveil primary tumor immunogenicity while activating adaptive immunity to suppress distant metastases.
Programmed raspberry-structured nanoadjuvants were developed via self-assembly of indoleamine 2,3-dioxygenase 1 inhibitor modified with small-sized copper sulfide nanoparticles and a cationized polymeric matrix that was sensitive to the tumor microenvironment . Related StoriesPhotothermal therapy can be an effective anti-tumor therapy, but it may not eliminate tumor cells, leading to the risk of recurrence or metastasis. Moreover, due to poor penetration ability, PTA was not efficient in inducing immunogenicity in deep tumor tissues and caused an inhomogeneous release of DAMPs, making the localized tumor regions “cold” towards immunotherapy.
Thus, accumulation of CTLs at tumor sites, regulation of immunosuppressive TME, and systemic immune surveillance are effective strategies to inhibit primary tumor growth and metastasis. The present work proposed a NIR-II photo-immunometabolic cancer therapy, utilizing programmed raspberry-shaped nanoadjuvants with transformable charge and size and immunometabolic regulation ability in deep tumor tissues.
Belgique Dernières Nouvelles, Belgique Actualités
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