Repeated COVID-19 vaccination may improve public health outcomes dartmouth medrxivpreprint COVID19 SARSCoV2 Vaccination PublicHealth Outcome
By Dr. Sanchari Sinha Dutta, Ph.D.Feb 1 2023Reviewed by Benedette Cuffari, M.Sc. A recent study posted to the medRxiv* preprint server suggests that repeated vaccination at frequent intervals might improve coronavirus disease 2019 vaccine efficacy and the trajectory of the pandemic.
In an attempt to increase vaccine efficacy, as well as achieve a robust and durable neutralizing antibody response, booster vaccine doses have been introduced in most countries throughout the world. Real-world studies have shown that booster doses are effective against VOCs. According to the model estimates, individuals vaccinated with one booster dose were expected to experience an average of 1.5 infections each year, whereas unvaccinated individuals were predicted to experience more than two infections each year. The risk of death was predicted to be two times higher among unvaccinated individuals as compared to boosted individuals.
A short antibody half-life of fewer than 50 days was identified as a major risk factor for breakthrough infections. These infections were found to significantly increase the risk of death. According to the model predictions, six vaccine doses per year could reduce the risk of infection in a high-risk population.
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